Buffalo Bills vs. Arizona Cardinals 
So, the Cardinals are indeed 4-1 and a perfect 3-0 at home. But man, this has got to be one of the worst 4-1 teams I've seen in a while. 
I'm just not sold on Arizona, at least not on both sides of the ball. There's just no way this offense will be able to score enough points to keep up.
Ryan FitzpatrickCapper Dave Lawrence is not sold on this team either, and he has decided to add this matchup to his Week 6 NFL Fades article. Not being able to trust this team does add to the risk, but I believe that this opens up great value for bettors willing to take a shot on the Bills.
That Cardinals defense has been exceptional, ranking #11 in total defense, a meteoric rise from last season. But the offense? They're #31 in the NFL in total yards and just lost Ryan Williams for the season too, just a couple weeks after Beanie Wells went down. 
It's not like either of those two backs were tearing it up, but it's hard to imagine that dismal rushing attack getting any better with the likes of LaRod Stephens-Howling and Williams Powell back there now.
That leaves Kevin Kolb with the enormous responsibility of running a highly imbalanced offense. 
This seems like a good time to sell high on the Cardinals. After Buffalo, they have road games against Minnesota and Green Bay and a home matchup with San Francisco over the next month. This team could easily be 5-4 or even 4-5 heading into their Week 10 BYE. 
Buffalo's been quite terrible over the last two weeks, but there's a little thing called pride that I think the Bills will come out with this weekend. They have Fred Jackson and C.J. Spiller back and relatively healthy and Ryan Fitzpatrick, despite his unacceptable turnover rate, has been making some big plays in the passing game this season.
Pick: Buffalo Bills +4.5 +++
New England Patriots vs. Seattle Seahawks 
The Patriots have built up some momentum with two straight wins, their latest a 31-21 triumph over Peyton Manning and the Denver Broncos in Week 5. 
In my estimation, it will be a third straight victory after this weekend's game against the Seahawks is said and done.
New England PatriotsSeattle's defense is no joke. They're ranked number one and rightfully so after holding the Dallas Cowboys to seven points and the Green Bay Packers to twelve.
Even so, I don't see this as a good matchup for the Seahawks. The Patriots have the league's best offense right now (439.4 yards per game), with both their running and passing games spotted up in the top ten.
There also seems to be a legitimate chance Aaron Hernandez will return to the field this weekend. He almost was ready to go last weekend and another full week should be put him in a great position to get back out there. Tom Brady will love having yet another deadly weapon in the passing game to turn to.
Moreover, Brady has actually been better on the road than at home this season. In three games outside of Foxborough he's thrown six touchdown passes without any interceptions and has a rating of 112.1. 
The Seahawks are just two one-dimensional offensively. Marshawn Lynch has been a beast, but sooner or later the impetus is going to fall on Russell Wilson to make stuff happen. New England is doing well against the run (82.2 YPG allowed) so maybe that day will come on Sunday.
It's always a risk betting against Seattle at home, but New England is much more balanced and obviously much more dangerous on the offensive side of things. Add the Pats to your NFL picks.
Pick: New England Patriots -3.5 ---